Predicts 10-year mortality based on 19 comorbid conditions plus age.
When to use: Used to adjust for comorbid burden in clinical studies, operative risk stratification, and prognosis discussions. Frequently used in oncology and surgery to guide treatment decisions based on life expectancy.
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Formula
CCI = Sum of weighted comorbidity points + Age adjustment
Age 40–49: +1, 50–59: +2, 60–69: +3, ≥70: +4
Key Points for NEET PG
CCI is the most widely validated comorbidity index — used in >10,000 studies
Age-adjusted CCI adds age points: 1 point per decade after age 40
Metastatic cancer (+6) and AIDS (+6) are the highest weighted conditions — often dominate the score
CCI frequently used in oncology to determine if patients can tolerate chemotherapy
Leukemia and lymphoma are separate entries in the original CCI (both +2)
References
A new method of classifying prognostic comorbidity in longitudinal studies · Journal of Chronic Diseases (1987)
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